Michael C. Tobes, M.D., PhD., F.A.C.C.

Address
1212 South Palestine
Athens, TX 75751-3619

Telephone: (903) 675-6800
Fax: (903) 670-1134

Private Practice

• 1997-Present: Cardiovascular Associates of East Texas, P.A., Athens, Texas

General Education

• 1966 - 1970: Michigan State University - East Lansing, Michigan, Bachelor of Science Degree
• 1970 - 1972: University of Michigan - Ann Arbor, Michigan, Master of Science Degree, (Biology and Chemistry)
• 1972 - 1976: University of Michigan - Ann Arbor, Michigan, Doctor of Philosophy Degree, (Biology and Chemistry)
• 1976 - 1979: University of Michigan - Ann Arbor, Michigan, Post Doctoral Degree - Nuclear Medicine

Medical Education

• 1988 - 1990: University of Miami School of Medicine - Miami, Florida, Doctor of Philosophy to Doctor of Medicine Program
• 1990 - 1993: Medical Residency - Internal Medicine, Pennsylvania State University, The Milton S. Hershey Medical Center
• 1993 - 1996: Fellowship - Henry Ford Hospital, Division of Cardiovascular Medicine

Medical Licensure

• State of Michigan, Permanent 1994 to Present
• State of Texas

Hospital Appointments

• 1997: Active - East Texas Medical Center - Athens, TX
• 1997: Consulting - East Texas Medical Center, Tyler,TX
• 1997: Consulting - Trinity Mother Frances Hospital, Tyler, TX

Professional Organizations

• 1975 - 1987: Member, American Association for the Advancement of Science
• 1981 - 1988: Member, Society of Nuclear Medicine
• 1983 - 1987: Member, American Chemical Society
• 1985 - 1988: Member, Radiopharmaceutical Science Council of the Society of Nuclear Medicine
• 1988: Member, Computer Council of the Society of Nuclear Medicine

Professional Committees

• 1983 - 1985: Member, Advisory Committee on Primary Research Appointments, Promotions, and Titles (APRAPT) of the University of Michigan Medical School
• 1981, 1996, 1987: Referee, Journal of Nuclear Medicine

Administrative Duties

• 1979 - 1985: Director, Nuclear Medicine Biochemistry Research Unit, Department of Internal Medicine, Ann Arbor, Michigan

Teaching Appointment

• 1979 - 1984: E.I.H. 509, Environmental Carcinogenesis - Department of Industrial and Environmental Health, Director - Dr. Bruce Chin

Professional Appointments

• 1985 - 1988: Member of Technical Staff - Medical Diagnosis Systems Laboratory, AT&T Bell Laboratories
• 1981 - 1985: Assistant Research Scientist - Department of Internal Medicine, Division of Nuclear Medicine, The University of Michigan, Ann Arbor, Michigan
• 1979 - 1981: Research Investigator - Department of Internal Medicine, Division of Nuclear Medicine, The University of Michigan, Ann Arbor Michigan
• 1979: Postdoctoral Scholar - Department of Biological Chemistry Director - Dr. Merle Mason, Department of Internal Medicine, Director - Dr. William H. Beierwaltes, The University of Michigan, Ann Arbor, Michigan

Honors/Awards

• 1970: Michigan State University, East Lansing, MI, Bachelor of Science, Biochemistry Cum Laude
• 1997 - 1980: National Research Service Award

Textbooks

• Wieland, D.M., Tobes, M.C., and Mangner, T.J., Eds.: Analytical and Chromatographic Techniques in Radiopharmaceutical Chemistry. Springer-Verlag, Inc., New York, 1986.
• Tobes, M.C., Kynurenine Aminotransferase from Rat Kidney. Academic Press, Inc., Orlando, Florida, Methods Enzymol.142: 217-224, 1987.

Grants/Research

• 1980 - 1983: Co-Principal Investigator - NIH Grant - 1-RO1-CA- 27244: "Mechanism-based Inhibitors of Diamine Oxidase."
• 1983 - 1984: Co-Principal Investigator - Merrell Dow Pharmaceuticals, Inc., Merrell Research Center Grant: A Phase I Clinical Study of Combination of DFMO and MGBG: Pharmacokinetic, Cellular, Biochemical, Pharmacological and Cytokinetic Effects®.
• 1981 - 1984: Co-Principal Investigator - NIH Grant - 1-R01-HL- 27555: "Heart Imaging Agents: A Structural- Mechanistic Study."
• 1981 - 1984: Co-Investigator - DOE Grant - DE-AC02-76EV02031: "Radiopharmaceuticals for Diagnosis and Treatment."
• 1982 - 1986 Principal Investigator - NIH Grant - 1RO1-CA-32878: "Enzyme Inhibitors as Radiopharmaceutical Agents."
• 1984 - 1986: Co-Principal Investigator - NIAMDD Grant AM-21477: "Radionuclide Adrenal Imaging in Hypertension."
• 1985 - 1988: Co-Principal Investigator - NIH Grant -HL 27555: "HeartImaging Agents: A Structural Mechanistic Study."
• 1984 - 1985: Co-Investigator - NIH Grant 1-510-RR-02387: "Radionuclide Tomographic Camera and Dedicated Computer."
• 1984 - 1985: Co-investigator-PRAISE 2 - (Prospective Randomized Amlodipine Survival Evaluation - 2) Phase III Protocol NO. 053-185: A randomized, double-blind, dose-titration, parallel group, placebo-controlled study to evaluate the effect of Amlodipine on survival in patients with congestive heart failure.
• 1984 - 1985: Co-Investigator - Paragon B Trial: A randomized, double-blind, placebo-controlled study of Lamifiban (RO44-9883) in patients with unstable angina/non-Q wave myocardial infarction.
• 1984 - 1985: Co-investigator - Niaspan Trial #MA-97-0101 Phase IV: an open-label, community-based clinical practice study of Niaspan in patients with hyperlipidemia.

Publications

1. Tobes, M., Kuczenski, T.R., and Suelter, C.H.: Yeast Pyruvate Kinase Renaturation after Dissociation by Guanidine. HCI. Arch. Biophys. 151:56-61, 1972.

2. Mason, M., Tobes, M.C., and Manning, B.: Factors Affecting the Access of Mitochondrial Kynurenine Aminotransferase to its Substrates. Aeta Vitamin. Enzymol. 29: 301-317, 1975.

3. Tobes, M.C. and Mason, M.: L- Kynurenine Aminotransferase and L-alpha-Aminoadipate Aminotransferase. I. Evidence for Identity. Biochem. Biophys. Res. Commun. 62: 390-379,1975.

4. Mason, M. and Tobes, M.D.: Opposing Actions of Ca++ and ATP Plus Mg++ in controlling in the Kynurenine Aminotransferase Activity of Isolated Rat Kidney Mitochondria. Biochem, Biophys. Res. Commun. 75: 434-441, 1977.

5. Tobes, M.C., and Mason, M.: alpha- Aminoadipate Aminotransferase and Kynurenine Aminotransferase: Purification, Characterization and further Evidence for Identity. J. Biol. Chem. 242: 4591-4599, 1977.

6. Tobes, M.C., and Mason, M: Kynurenine Aminotransferase and alpha-Aminotransferase: III. Evidence for Identity with Halogenated Tyrosine Aminotransferase. Life Sci. 22: 793-802, 1978.

7. Wieland, D.M., Brown, I.F., Tobes, M.D., Rogers W.L., Marsh, D.D., Mangner, T.J., Swanson,D.P., and Beierwaltes, W.H.: Imaging the Primate Adrenal Medullac with [131] Meta-Iodobenzylguanidine. J. Nucl. Med. 22: 358-364, 1981.

8. Sisson, J.C., Frager, M.S., Valk, T.W., Gross, M.D., Swanson, D.P., Wieland, D.M., Tobes, M.C., Beierwaltes, W.H., and Thompson, N.W.: Scintigraphic Location of Pheochromocytoma. N. Eng. J. Med. 305: 12-12., 1981.

9. Weiss, R.J., Tobes, M., Wertz, C.E., and Smith, C.B.: Platelet Alpha 2 Adrenoreceptors in Patients with Congestive Heart Failure. Am. J. Cardiol. 52: 101-105., 1983.

10. Tobes, M.C., Brown, L.E., Chin, B., and Marsh D.D.: Kinetics of Tissue Distribution and Elimination of 4.4- Methylenebis (2-Chloroaniline) in Rats. Toxicology Letters 17: 69-75, 1993.

11. Chin, B., Tobes, M.C., and Han, S.S.: Absorption of 4.4- Methylenebis (2-Chloroaniline) by Human Skin. Environ. Res. 32: 167-178, 1983.

12. Hays, S.J., Tobes, M.C., Gildersleeve, D.L., Wieland, D.M., and Beierwaltes, W.H..: Structure-Activity Relationship Study of the Inhibition of Adrenal Cortical 11-beta-Hydroxylase by new Metyrapone Analogues. J. Med. Chem. 27: 15-19, 1984.

13. Jacques, Jr., S., Tobes, M.D., Sisson, J.C., Baker, J.A., and Wieland, D.M.: Comparison of the Sodium-Dependency of the Uptake of Meta-Iodobenzylguanidine to Norepinephrine into Culture Bovine Adrenomedullary Cells. Molec. Pharmacol. 26: 539-546, 1984.

14. Tobes, M.D., Hay, S.C., Gildersleeve, D.L., Wieland, D.M., and Beierwaltes, W.H.: II Adrenal Cortical 11-beta-Hydroxylase and Side-Chain Cleavage Enzymes. Requirement for the A- or B- Pyridyl Ring in Metyrapone for inhibition. J. Steroid Biochem. 22: 103-110, 1985.

15. Tobes, M.C., Jacques, Jr., S., Wieland, D.M., and Sisson, J.C.: Effect of Uptake-One Inhibitors on the Uptake of Norepinephrine and Metaiodobenzylguanidine. J. Nucl. Med. 26: 897-907, 1985.

16. Gildersleeve, D.L., Tobes, M.D., and Natale, R.B.: Rapid Analysis for Methyglyoxal Bis (guanylhydrazone) by Reversed-Phased Ion-Pair Liquid Chromatography. Clin. chem. 31: 1979-1984, 1984.

17. Mangner, J.T., Tobes, M.C., Wieland, D.M., Sisson, J.C., and Shapiro, B.: Metabolism of Iodine-131 Metaiodobenzylguanidine in Patients with Metastatic Pheochromocytoma. J. Nucl. Med. 27: 37-44, 1986.

18. Shulkin, B.L., Shapiro, B., Tobes, M.C., Shen, S.W., Wieland, D.M., Meyers, L.J., Lee, H.T., Petry, N.A., Sisson, J.C., and Beierwaltes, W.H.: Iodine-4-Amino-3-Iodobenzylguanidine, a New Sympathoadrenal Imaging Agent: Comparison with Iodine-123 Metaiodobenzylguanidine. J. Nucl. Med. 27: 1138-1142, 1986.

19. Jacques, Jr., S. and Tobes, M.D.: Morphologic and Biochemical Variability of Tissue and Cultured Cells From Human Pheochromocytoma. J. Cell. Physiol. 128: 261-270, 1986.

20. Sisson, J.C., Wieland, D.M., Sherman, P., Mangner, T.J., Tobes, M.C., and Jacques, Jr., S.: Metaiodobenzylguanidine as an Index of the Adrenergic Nervous System Integrity and Function. J. Nucl. Med. 28: 1620-1624, 1987.

21. Jacques, Jr., S., Tobes, M.C., and Sisson, J.C.: Sodium Dependency of Uptake of Norepinephrine and m-Iodobenzyguanidine into Cultured Human Pheochromocytoma Cells: Evidence for Uptake-One. Cancer Res. 47: 3920-3928, 1987.

22. Tobes, M.C., Schonfeld, S.M., Mezrich, R.S., Amorosa, J.K., Needell, G.S., and Safer, J.N.: Teleradiology Operations within a PACS Environment. S.P.I.E. 767: 849-852., 1987.

23. Tobes, M.C., Fig, L.M., Carey J., Geatti, O., Sisson, J.C., and Shapiro, B.: Alterations of 131 I Metaiodobenzyguanidine (131 I-MIBG) Biodistribution in an Anephric Patient: Comparison to Normal and Impaired Renal Function. J. Nucl. Med. 30: 1476-1482, 1989.