Richard W. Lowry, M.D., F.A.C.C.

1979-1983: Stanford University, Palo Alto, California, Bachelor of Arts in Human Biology, 1983
1983-1987: University of Oklahoma College of Medicine, Oklahoma City, Oklahoma. Doctor of Medicine,1987

Post-Graduate Training

7/1987-6/1988: Internship in Medicine, Charity Hospital, Veterans Administration Hospital and Tulane Medical Center, New Orleans, Louisiana
7/1988-6/1990: Residency in Medicine, Charity Hospital, Veterans Administration Hospital and Tulane Medical Center, New Orleans, Louisiana
7/1990-6/1994 Fellowship in Cardiology, Baylor College of Medicine Affiliated Hospitals, Houston, Texas
7/1993-6/1993 Fellowship in Interventional Cardiology, Baylor College of Medicine Affiliated Hospitals, Houston, Texas

BOARD CERTIFICATION

1990: American Board of Internal Medicine. September 12, 1990 #134899
1993,2003: American Board of Internal Medicine, Subspecialty Board of Cardiovascular Disease #134899
1999: American Board of Internal Medicine, Subspecialty Board of Interventional Cardiology #134899

HOSPITAL APPOINTMENTS

2006-Present: Trinity Mother Frances Hospital, Tyler, Texas
2006-Present: East Texas Medical Center-Tyler, Tyler, Texas

MEMBERSHIPS

American Medical Association
American College of Physicians
Fellow of American College of Cardiology - 1995
Oklahoma Medical Society
Tulsa County Medical Society
Fellow of The Society for Cardiac Angiography & Interventions, 2001

PROFESSIONAL ACTIVITIES

1997-Present: Medical Advisory Board Scimed
1999-Present: Editorial Consultant, The Society for Cardiac Angiography & Interventions

HONORS AND AWARDS

1986-1987: Presbyterian-Harris Foundation Scholarship
1987: Student Research Award, The Southern Section of American Federation
1990-1991: Appointed Chief Resident for Tulane University, Department of Medicine

WORK HISTORY

1982-1983: Stanford University Department of Neuropsychology- Research Assistant (RA) for Richard Thompson, Ph.D.
1984: University of Oklahoma, Department of Urology, Research Assistant for George Hemstreet, M.D.
1986-1987: University of Oklahoma, Department of Endocrinology, Research with Atrial Natriuretic peptide and Pacemakers, RA for David Kem, M.D.
1987-1989: American Diabetes Association Summer Camp, Staff Physician
1989: Tulane University, Department of Nephrology, Research with Calcium Channel Blockers for Hypertensive Emergencies. RA for Eileen Cook, M.D.
1989-1990: Tulane University, Department of Cardiology - Basic Research with Diabetic-Hypertensive Cardiomyopathy. RA for Thomas Giles, M.D.
1989-1990: Tulane University Medical Student Advisor and Preceptor for Physical Diagnosis Course.
1991-1992: Baylor College of Medicine, Department of Cardiology, Clinical Research Fellow for Congestive Heart Failure Trials
1991-1992: Baylor College of Medicine, Department of Cardiology, Transplant Clinical Research Fellow. (One year of concentrated clinical and research training in congestive heart failure and cardiopulmonary transplantation. Techniques learned included myocardial biopsy and use of ventricular assist devices.)
1993-1994 Baylor College of Medicine, Department of Cardiology, Interventional Cardiology Fellow. (One year of extensive clinical training in interventional techniques including PTCA, directional athrectomy, laser, peripheral angioplasty and intravascular Doppler/ultrasound imaging.)

RESEARCH

BEST - Beta-blocker evaluation of survival trial. Mortality study to evaluate Bucindolol versus placebo in patients with Class III/IV CHF and EF < 35%. (NHLBI & VA Cooperative Studies Program)
PRAISE-2 - Prospective Randomized Amlodipine Survival Evaluation-2. To evaluate the effect of amlodipine on survival in patients with congestive heart failure (non-ischemic etiology) and EF < 30%. No beta blocker allowed. (Pfizer, Inc.)
Val-Heft - Valsartan in heart failure. Placebo controlled study to evaluate the effect of Valsartan on morbidity and mortality, signs and symptoms and quality of life in patients with stable, chronic CHF (NYHA Class II-IV). EF < 40%. May be on beta blocker. (Novartis)
SCD-HeFT - Sudden cardiac death in heart failure trial. Amiodarone vs. an implantable cardioverter - defibrillator (ICD) vs. placebo (I:I:I) in the treatment of patients with NYHA II/III CHF. EF < 35%. (NHLBI)
RENAISSANCE - Multi-center, double-blind, randomized, placebo-controlled, Phase II/III study of the effect of recombinant human tumor necrosis factor receptor Fe fusion protein (TNFR:Fe)(etanercept) on clinical improvement in patients with chronic heart failure.
SPORT - Stent implantation post rotational athrectomy trial.
ULTRA - ULTRA-GX 2.5 acute or threatened closure registry.
MOXCON - The effect of sustained release moxonidine on mortality and morbidity in patients with congestive heart failure.
ATP - The effect of LDL-cholesterol lowering beyond currently recommended minimum targets on coronary heart disease (CHD) recurrence in patients with pre-existing CHD.
MUSTT - Multi-centered unsustained tachycardia trial.
OPUS/TIMI 16 - Phase III international randomized double-blind placebo-controlled trial evaluating the efficacy and safety of Orbofiban in patients with unstable coronary syndromes.
TcN-NOET - Cardiac imaging agent.
Wallstent Study - WIN - Wallstent in native coronary arteries. Nonrandomized - all patients who qualify get Wallstent. WINS - Wallstent in SV-CABG vessels. Randomized to Wallstent or J&J stent (1:1). (Schneider)
In Time-II - Double-blind, randomized, multicenter trial of single-bolus Lanoteplase versus accelerated alteplase for the treatment of subjects with acute myocardial infarction. Randomized 2:1, chest pain x 30 minutes within 6 hours. (Bristol-Myers Squibb).
SADHART - A randomized double-blind, placebo-controlled trial of sertraline (Zoloft) for major depression after myocardial infarction. MI within 30 days. (Pfizer and Duke).
GEM DR - Evaluation of patients implanted with an implantable cardioverter defibrillator combined with a dual chamber rate responsive pacemaker. Inclusion criteria: one episode of sudden cardiac death or recurrent poorly tolerated sutained VT. (Medtronic)
Destini-FloWire Registry - Any patient who undergoes evaluation with a FloWire should be entered in this registry. (Cardiometrics).

PUBLICATIONS

Manuscripts

Fujimaro A, Lowry RW , Kem DC, "Calcium infusion increases plasma atrial natriuretic peptide in spontaneously hypertensive rats." Hypertension 1989;14:98-103.
Lowry RW, Young JB. "Non-invasive techniques to determine cardiac allograft rejection. In: Cardiac Transplantation and Mechanical Circulatory Support." Frazier OH, Radiovancevic B (eds). J.B. Lippincott 1992 (Book Chapter in Press).
Young JB, Smart FM, Lowry RW , Kleiman NS. Coronary angiography after heart transplantation: Should perioperative study be the "gold standard"? J Heart Lung Transplant 1992; 11:S65-68.
Young JB, Windsor NT, Kleiman NS, Lowry RW , Cocanougher B, Lawrence EC. "The relationship of soluble interleukin-2 receptor levels to allograft arteriopathy after heart transplantation." J Heart Lung Transplant 1992;11:S79-82.
Halle A, Wilson R, Massin E, et al: "Coronary angioplasty in cardiac transplant patients: Results of a multicenter study." (Listed as a co-investigator) Circulation 1992;86:458-62.
Cocanougher B, Ballantyne CM, Pollack MS, Payton-Ross C, Lowry RW , Kleiman NS, Farmer JA, Noon GP, Short HD, Young JB. "Degree of HLA mismatch as a predictor of death from allograft arteriopathy after heart transplantation." Transplantation Proceedings 1993. 25(1):223-236.
Lowry RW , Young JB, Kleiman NS, Zoghbi WA. "Demonstration of right coronary artery to coronary sinus fistula in a heart transplant recipient by transesophageal echocardiography." (Submitted to J Am Soc Echo)(Accepted Jan 1993).
Lowry R , Adam E, Hu C, Kleiman N, Cocanougher B, Windsor N, Bitar J, Melnick J, Young: "What are the implications of cardiac infection with cytomegalovirus prior to cardiac transplantation?" J Heart Lung Transplant 1993; (Accepted May, 1993).
Lowry R, Kleiman N, Raizner A, Young J: "Is intravascular ultrasound better than quantitative coronary arteriography to assess cardiac allograft arteriography?" Catheterization and Cardiovascular Diagnosis 1993;(Accepted August, 1993).
Lowry R, Zoghbi W, Baker W, Wray R, Quinones M: "The clinical impact of transesophageal echocardiography in the diagnosis and management of infective endocarditis: Significance of negative findings." Am J Cardiology, May 1994 (Accepted September, 1993).
Lowry R , Bitar J, Grinstead C, Young J, Noon G, Vardan S, Cocanougher B, Kleiman N: "The heterotopic heart transplant: Donor right heart catheterization, endomyocardial biopsy and coronary angiographic techniques." Catheterization and Cardiovascular Diagnosis, (Accepted January, 1994).
Lowry R, Adam E, Hu C, Kleiman N, Cocanougher B, Windsor N, Bitar J, Melnick J, Melnick J, Young J: "What are the Implications of Cardiac Infection with Cytomegalovirus before Heart Transplantation?" J Heart Lung Transplant 1994;13(1,1):122-128.
Lowry R , Kleiman N, Raizner A, Young J: "Is Intravascular Ultrasound Better than Quantitative Coronary Arteriography to Assess Cardiac Allograft Arteriopathy?" Catheterization and Cardiovascular Diagnosis 1994;31:110-115.
Lowry R , Young J, Kleiman N, Zoghbi W: "Transesophageal Echocardiographic Demonstration of Right Coronary Artery -to- Coronary Sinus Fistula in a Heart Transplant Recipient". J Am Soc Echo 1993;6(4):449-452.
Medrano R, Lowry R , Young J, Weilbaecher D, Michael L, Afridi I, He Z, Mahmarian J, Cerani M: "Assessment of Myocardial Viability with Technetium-99m Sestamibi in Patients Undergoing Cardiac Transplantation: A Scintigraphic-Pathologic Study." Circulation Vol 94, No 5, Sept. 1, 1996:1010-1017.

Abstracts

Lowry RW , Zoghbi WA, Baker WB, Wray RA, Quinones MA. "Clinical impact of a negative transesophageal echocardiographic study in patients undergoing evaluation for endocarditis." Presented at the American College of Cardiology 41 st Annual Scientific Sessions, 1992.
Medrano R, Weilbaecher D, Young J, Mahmarian J, Guidry G, Lowry R , Michael L, Verani M: "Assessment of myocardial viability with technetium-99m sestamibi in patients undergoing cardiac transplantation: A scintigraphic-pathologic study." Accepted for presentation at the American Heart Association 65 th Annual Scientific Sessions, 1992.
Lowry R, Kleiman N, Raizner A, Young J: "Is intravascular ultrasound better than quantitative coronary arteriography to assess cardiac allograft arteriopathy?" Presented at the American College of Cardiology 42 nd Annual Scientific Session, 1993.
Lowry R , Adam E, Bitar J, Kleiman N, Cocanougher B, Windsor N, Hu C, Melnick J, Young J: "What are the implications of cardiac infection with cytomegalovirus prior to cardiac transplantation?" Presented at the International Society for Heart and Lung Transplantation 13 th Annual Meeting and Scientific Sessions, 1993.
Bitar J, Vardan S, Lowry R , Farmer J, Cocanougher B, Zoghbi W, Kleiman N, Short H, Noon G, Young J: "Fate of the native heart after heterotopic cardiac transplantation: An echocardiographic study." Accepted for presentation at the American Society of Transplant Physicians 12 th Annual Scientific Meeting, 1993.
Vardan S, Bitar J, Lowry R , Farmer J, Kleiman N, Cocanougher B, Short H, Noon G, Young J: "The evolution of hemodynamic parameters following heterotopic cardiac transplantation." Accepted for presentation at the American Society of Transplant Physicians 12 th Annual Scientific Meeting, 1993.
Lowry R , Tawa C, Hays J, Churchill D, Grinstead C, Marks G, Chesnick P, Raizner A, Kleiman N: "Which factors predict successful reattachment of angioplasty-induced dissections using perfusion ballons?" Presented at The Society for Cardiac Angiography and Interventions 16 th Annual Meeting, 1993.
Junichi N, Lowry R , Chakravarthy R, Freeman M, Berrier H, Khoury D, Zhu W, Rizo-Patron C, Young J, Maloney J: "Long-Term Follow-up of Cardiac Transplant Recipients Requiring Permanent Pacemakers." Accepted for presentation at the American College of Cardiology 43 rd Annual Scientific Sessions, 1994.
Ali N, Lowry R , Tawa C, Joseph J, Abukhalil J, Marks G, DeFelice C, Kleiman N, Raizner A: "Predictors of restenosis after Gianturco-Roubin coronary stent deployment. Analysis of 135 consecutive patients form a single center." Accepted for presentation at the American College of Cardiology 43 rd Annual Scientific Session, 1994.
Nitta J, Lowry R , Chakravarthy R, Freeman M, Berrier H, Khoury D, Zhu W, Rizo-Patron C, Young J, Maloney J, Baylor College of Medicine: "Long-Term Follow-up of Cardiac Transplant Recipients Requiring Permanent Pacemakers." Accepted for presentation at the American College of Cardiology 43 rd Annual Scientific Session, 1994.
Tawa C, Ali N, Lowry R , Joseph J, Abukhalil J, Marks G, DeFelice C, Kleiman N, Raizner A, The Methodist Hospital, Baylor College of Medicine: "Predictors of Clinical Events Six Months After Stenting With the Gianturco-Roubin Coronary Stent". Accepted for presentation at the 16 th Annual Meeting of The Society for Cardiac Angiography and Interventions, May 20-22, 1993.