Sherif S. Iskander, M.D., F.A.C.C.

Address:
115 W. Fifth Street
Tyler, TX 75703

Telephone: (903) 595-2283
Fax: (903) 597-2238

Private Practice

• 2001-Present: Cardiovascular Associates of East Texas, P.A., Tyler, Texas

Education

• 1977-1980: High School Alexandria, Egypt
• GSECE - General Secondary Education Certificate, Victory College

Academic Degrees

• 1980-1981.1: Premedical Education - Alexandria University, Alexandria, Egypt, Faculty of Science
• 1981-1989.1: MD Degree - Alexandria University, Alexandria, Egypt, Faculty of Medicine

Post Graduate Education & Experience

• 1990-1991: Internship Rotation, Alexandria University Hospital, Alexandria, Egypt
• 1991-1992: Family Practitioner, Public Medical Center, Moharem Bek, Alexandria, Egypt
• 1992-1994: Internal Medicine, Summit Medical Center, Union City, New Jersey
• 1994-1995: Transitional Year, New York Hospital Medical Center of Queens, Flushing, New York
• 1995-1998: Internal Medicine Residency, Hahnemann University, Philadelphia, PA
• 1998-2001: Cardiology Fellowship, Baylor College of Medicine Affiliated Hospitals, Houston, TX
• 1999-2000: Nuclear Cardiology Fellowship, The Methodist Hospital, Baylor College of Medicine
• 1999: Safe Use of Radioactive Materials in Medical Imaging for nuclear license certification
• 2001-Present: Director of Nuclear cardiology laboratory, Invasive cardiologist, Cardiovascular Associates of East Texas, Tyler, TX
• May 2001: Faces of CAD Speaker Training Meeting I., Las Vegas, Nevada
• January 17-19, 2002: Faces of CAD Speaker Training Meeting II., Santa Barbara, California
• November 22-23, 2002: Advances in Vascular Diagnostics Symposium

• 1991: Education Commission for Foreign Medical Graduate (ECFMG)
• 1998: Internal Medicine Board Certification
• 2000: Nuclear Cardiology Board Certification
• 2001: Cardiovascular Disease Board Certification

• 1991: Egyptian Medicine and Surgery License, 104705
• 1995: Pennsylvania State License, MD-066237-L
• 1999: Texas State Board of Medical Examiners, K7304
• 2000: Nuclear Cardiology, #L04800

Hospital Appointments

• 2001-Present: Acting Staff - Trinity Mother Frances Hospital, Tyler, Texas
• 2001-Present: Acting Staff - East Texas Medical Center Hospital, Tyler, Texas

Professional Societies and Other Memberships

• American College of Physicians
• American Medical Association
• Fellow, American College of Cardiology
• American Society of Nuclear Cardiology
• American Society of Echocardiography

Research

• Co-Investigator – RESOLUTE US - A Clinical Evaluation of the Medtronic Endeavor® Resolute
  Zotarolimus-Eluting Coronary Stent System in the Treatment of De Novo Lesions in Native Coronary Arteries with a Reference Vessel Diameter
  of 2.25 mm to 4.2 mm
• Co-Investigator -  PLATO Study - A Randomized, Double-blind, Parallel Group, Phase 3, Efficacy and Safety Study of AZD6140 Compared with Clopidogrel for Prevention of Vascular Events in Patients with Non-ST or ST Elevation Acute Coronary Syndromes (ACS).
• Co-Investigator - XIENCE™ V:  Everolimus Eluting Coronary Stent System (EECSS) USA Post-Approval Study sponsored by Abbott Vascular Inc.
• Co-Investigator – ENDEAVOR IV – A Randomized, Controlled Trial of the Medtronic Endeavor Drug Eluting Coronary Stent System versus the Taxus Paclitaxel-Eluting Coronary Stent System in De Novo Native Coronary Artery Lesions.
• Primary Investigator – VISION 305 Study - “Vasodilator Induced Stress In Concordance with Adenosine” A multicenter, risk-stratified, randomized, double-blind, double-dummy study drug administration, active-controlled, complete two-arm crossover study with a reference third arm.
• Co-Investigator – RE-LY Study - Randomized Evaluation of Long term anticoagulant therapy (RE-LY) comparing the efficacy and safety of two blinded doses of dabigatran etexilate with open label warfarin for the prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation: prospective, multi-centre, parallel-group, non-inferiority trial.
• Co-Investigator – A-HeFT - A Placebo-Controlled Trial of Bidil Added to Standard Therapy In African-American Patients with Heart Failure.
• Primary Investigator – ACCOMPLISH - A prospective, multicenter, double-blind, randomized, active-controlled trial to compare the effects of Lotrel (amlodipine/benazepril to benazepril and hydrochlorothiazide combined on the reduction of cardiovascular morbidity and mortality in patients with high risk hypertension.
• Co-Investigator - AMIHOT II – A prospective, Multi-center, randomized study of Aqueous Oxygen Therapy for 90 minutes in Anterior Acute MI patients with successful PCI/stenting presenting within 6 hours from time of symptom onset until time of reperfusion.
• Co-Investigator – TIMI38/TRITON – A Comparison of CS-747 and Clopidrogrel in Acute Coronary Syndrome Patients who are to Undergo Percutaneous Coronary Intervention; a Phase III, multicenter, randomized, parallel-group, double-dummy, active controlled trial in patients with acute coronary syndrome (ACS), who are to undergo percutaneous coronary intervention (PCI).
  Co-Investigator - APEX-AMI Study - “A Multicenter, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study of Pexelizumab in Patients with Acute Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention.” (Assessment of PEXelizumab in Acute Myocardial Infarction)-APEX-AMI.
• Co-Investigator - ACUITY Trial- A randomized comparison of Angiomax (bivalirudin) versus Lovenox/Clexane (enoxaparin) in patients undergoing early invasive management for acute coronary syndrome without ST- segment elevation.
• Assessment of myocardial viability early after acute myocardial infarction by nitroglycerin-augmented Tc-99m sestamibi SPECT: Its role in predicting       improvement of segmental and global ventricular function after      revascularization. (ongoing)
• Tetrofosmin myocardial perfusion imaging early and six months after      percutaneous transluminal coronary angioplasty (PTCA) with and without      stenting: A prospective study. (ongoing)
• Principal Investigator - Extra Point.  Protocol # S1710202. Cardiovascular      Safety Study of Nicotine Transdermal System
• Principal investigator: INSPIRE: THE ADENOSINE SESTAMIBI SPECT       POST INFARCTION EVALUATION TRIAL.  A Randomized, Prospective      Multicenter Trial Evaluating the Role of Adenosine Tc-99m Sestamibi Single-      Photon Emission Computed Tomography for Assessing Risk and Therapeutic  Outcomes in Survivors of Acute Myocardial Infarction.
• Co-Investigator – SYNERGY - A Prospective, Randomized, Open-Label, Multicenter Study in Patients Presenting with Acute Coronary Syndromes Aventix Pharmaceuticals Protocol Number ENO.GMA.301.  IND# 31532
• Co-Investigator – A Double-Blind Comparison Of The Incidence Of Hypotension With Two Formulations Of Intravenous Amiodarone:  CordaroneÒ I.V. vs Amiodarone Aqueous I.V. Injection - Protocol No. 058K1-312-US 
• Co-Investigator – REPLACE II – A Randomized Evaluation in PCI Linking Angiomax to Reduce Clinical Events, Part 2: REPLACE – 2 (TMC-BIV-01-03)
• Co-Investigator – AMIHOT – TherOx Aqueous Oxygen System – Acute Myocardial Infarction with Hyperoxemic Therapy “AMIHOT” Phase II Clinical trial. A Randomized, Controlled, Multicenter Trial of Aqueous Oxygen Infusion for 90 Minutes Post-Primary PTCA/Stent Intervention in Acute Myocardial Infarction Patients.
• Co-Investigator – Otuska Protocol 21-98-214-01 CASTLE A Randomized, Double-Blind, Placebo-Controlled, Multicenter, Parallel-Arm, Study to Assess The Long-Term Effects of Pletalâ (Cilostazol) Versus Placebo Administered Orally to Patients with Intermittent Claudication Secondary to Peripheral Arterial Disease

Publications

• Mahmarian JJ, Shaw LJ, Filipchuk NG, Dakik HA, Iskander SS, Ruddy TD, Henzlova MJ, Keng F, Allam A, Moye LA, Pratt CM; INSPIRE investigators. A multinational study to establish the value of early adenosine technetium-99m sestamibi myocardial perfusion imaging in identifying a low-risk group for early hospital discharge after acute myocardial infarction. J Am Coll Cardiol. 2006 Dec 19;48(12):2448-57.
• Mahmarian JJ, Dakik HA, Filipchuk NG, Shaw LJ, Iskander SS, Ruddy TD, Keng F, Henzlova MJ, Allam A, Moye LA, Pratt CM; INSPIRE investigators. An Initial strategy of intensive medical therapy is comparable to that of coronary revascularization for suppression of scintigraphic ischemia in high-risk but stable survivors of acute myocardial infarction. J Am Coll Cardiol. 2006 Dec 19;48(12):2458-67.
• Iskander SS, Nagueh SF, Ostrowski ML, Reardon MJ.  Growth of a left atrial sarcoma followed by resection and autotransplantation.  Ann Thorac Surg. 2005 May; 79(5): 1771 – 4
• Plana JC, Iskander SS, Ostrowski ML, Howell JF, Kurrelmeyer K, Raizner AE, Zoghbi, WA.  Cardiac angiosarcoma: an unusual presentation simulating mitral stenosis and constrictive-effusive pericarditis.  J Am Soc Echocardiogr.2003 Dec; 16(12): 1331-3.
• Iskander SS, Alessi CR, Kleiman N, Mahmarian JJ, Verani MS. “Myocardial perfusion imaging early after PCI” Abstract at the International Nuclear Cardiology Meeting 03/2001. Vienna Austria.
• Iskander SS, Alessi CR, Kleiman N, Mahmarian JJ, Verani MS. Myocardial perfusion imaging ealy after percutaneous coronary intervention. Presented at The Golden Jubilee and 28th Annual Meeting of Egyptian Society of Cardiology, Cairo, Egpt, February 19-23, 2001.
• Iskander SS, Mahmarian JJ, Kleiman NS, Raizner AE, Verani MS. Myocardial stress perfusion imaging 1 day after percutaneous coronary intervention in the modern era. J Am Coll Cardiol 2001; 37 (supl A): 402A.
• Iskander SS, Pratt CM, Filipchuk NG, Ruddy TD, Dakik HA, Henzlova MJ, Verani MS, Shaw LJ, Mahmarian JJ for the INSPIRE investigators. Therapies for suppression of post-infarction myocardial ischemia. Preliminary results from the Adenosine Sestamibi Post-infarction Evaluation (INSPIRE) Trial. Circulation 2001;104 (suppl II):II-455.
• Iskander SS, Alessi  CR, Kleiman N, Mahmarian JJ, Verani MS. “Myocardial stress perfusion imaging 1 day after percutaneous coronary intervention in the modern era.”  Abstract at ACC 2001. Orlando Florida.
• Shimoni S, Zoghbi WA, Xie F, Kriesfeld D, Iskander S, Gobar L, Mikati IA, Abukhalil J, Verani MS, O’Leary EL, Porter TR.  Real-time assessment of myocardial perfusion and wall motion during bicycle and treadmill exercise echocardiography: Comparison with single photon emission computed tomography.  J Am Coll Cardiol 2001;37:741-7.
• Iskander S, Raible DG, Brozena SC, Gaitanaru DM, Ayala G, Iskandrian AE.  Acute alveolar hemorrhage and orthodeoxia induced by intravenous amiodarone.  Catheterization and Cardiovascular Interventions 1999;47:61-63.
• Iskander S, Iskandrian AE.  Prognostic utility of myocardial viability assessment.  The American Journal of Cardiology 1999 Mar 1:83(5):696-702, A7.
• Iskander S, Iskandrian AE. Risk assessment using single-photon emission computed tomographic technetium-99m sestamibi imaging Journal of the American College of Cardiology 1998 July;32(1):57-62
• John J Mahmarian, Neil G. Filipchuk, Leslee J. Shaw, Habib A. Dakik, Sherif S. Iskander, Terrence D. Ruddy, Craig M. Pratt, for the INSPIRE Investigators.
• Stress Myocardial Perfusion Scintigraphy for Tracking Prognosis and Monitoring the Success of Anti-ischemic Therapies in Stable Survivors of Acute Myocardial Infarction: Results from the AdenosINe Sestamibi Post-InfaRction Evaluation (INSPIRE) Trial. ACC 03/2004

Presentations

• 05/1997: “The role of inflammation in CAD” Internal Medicine Conference, Hahnemann University, Philadelphia, Pennsylvania
• 08/1998: “The role of SPECT in pre-op evaluation” Cardiac Catheterization Conference. Baylor College of Medicine, Houston, Texas
• 09/2000: Working Group Challenge, 5th Annual American Society of Nuclear Cardiology (ASNC) Symposium and Scientific Session, Chicago, Illinois
• 09/2000: Working Group Challenge, 5th Annual American Society of Nuclear Cardiology (ASNC) Symposium and Scientific Session, Chicago, Illinois
• 10/2000: Case Presentations, Quarterly Meeting of the Southwest Texas American Society of Nuclear Cardiology Working Group, Houston, Texas
• 12/2000: "The Role of SPECT in the Evaluation of Therapeutic Modalities Following MI and PCI", Cardiology Grand Rounds, University of Alabama at Birmingham, Birmingham, Alabama
• 12/2000: Case Presentations, The Methodist Hospital Monthly Nuclear Cardiology Conference, Baylor College of Medicine, Houston, Texas
• 12/2000: "SPECT Imaging Following MI and PCI", Cardiology Research Conference, Baylor College of Medicine, Houston, Texas
• 02/2001: “Myocardial perfusion imaging early after percutaneous coronary intervention”, Golden Jubilee Congress of the Egyption society of Cardiology.
• 02/2001: “The role of SPECT in the evaluation of theraputic modalities after acute myocardial infarction.”, Golden Jubilee Congress of the Egyptian society of Cardiology.
• 03/2001: “Myocardial stress perfusion imaging 1 day after percutaneous coronary intervention in the modern era. “Abstract at ACC 2001. Orlando, Florida.
• 11/2001: “Noninvasive testing in the evaluation of coronary artery disease”. Cardiology Grand Round. VA Hospital, Dallas, Texas
• 11/2001: “Risk Stratification and Prognosis of CAD”. Norman, Oklahoma
• 02/2002: “Therapies for suppression of post-infarction myocardial ischemia. Preliminary results from the Adenosine Sestamibi Post-infarction Evaluation (INSPIRE) Trial”. 29th Annual Scientific Meeting of the Egyptian Society of Cardiology.
• 02/2002: “The role of SPECT in the Risk Stratification and Prognosis of CAD”. 29th Annual Scientific Meeting of the Egyptian Society of Cardiology.
• 06/2002; “Practical application of Nuclear Cardiology. Risk stratification and patient management.” Omaha, Nebraska.
• 07/2002: “Myocardial Perfusion Imaging”:  Risk Stratification And Patient Management. Christus St. Michael Health System. Texarkana, Texas.
• 8/2002: “Women and CAD”. Nuclear Cardiology Symposium. Dallas, Texas.
• 10/2002: “The Role of SPECT in Pre-Op Evaluation”. ASNC symposium, Houston, Texas.
• 02/2003: “THE ROLE OF FOLLOW-UP IMAGING IN THE EVALUATION OF THERAPEUTIC MODALITIES AFTER MI AND PCI”. 30th Annual Scientific Meeting of the Egyptian Society of Cardiology.
• 02/2003: “Myocardial Perfusion Imaging: Risk Stratification and Patient Management”. 30th Annual Scientific Meeting of the Egyptian Society of Cardiology.
• 02/2003: “Women and CAD”. 30th Annual Scientific Meeting of the Egyptian Society of Cardiology.

Honors

• Victory College High School, Alexandria Egypt Among the top 5% nationwide in the final national examination
• Medical School honors:  Anatomy, Microbiology and Pharmacology Alexandria University, Faculty of Medicine, Alexandria, Egypt
• Internal Medicine Residency: Infectious Disease award

Scholarships

• Competitive scholarship, all years of medical education
• Alexandria University, Faculty of Medicine, Alexandria Egypt