Jeffrey G. Carr, M.D., F.A.C.C.

Address
115 West Fifth Street
Tyler, TX 75701

Telephone: (903) 595-2283
Fax: (903) 597-2238

Cardiology Practice

• 1994 - Present: Cardiovascular Associates of East Texas, P.A., Tyler, Texas

Education

Academic Degrees

• 1979 - 1983: University of California, Los Angeles, Bachelor of Science - Psychobiology
• 1984 - 1988: University of California, Los Angeles, School of Medicine - Doctor of Medicine

Post Graduate Training

Residency and Internship

• 1988 - 1991: Internal Medicine, UCLA Medical Center

Cardiology Fellowships

• 1991 - 1994: Cardiology Fellowship, UCLA Medical Center
• 1993 - 1994: Interventional Cardiology Fellowship, UCLA Medical Center

Board Certification

• 1991: Diplomate, American Board of Internal Medicine
• 1995: Diplomate, American Board of Internal Medicine - Cardiovascular Disease
• 2000: Diplomate, American Board of Internal Medicine - Interventional Cardiology

Medical Licensure

• State of Texas
• State of California

Hospital Appointments

• 1994 - Present: Acting Staff - Trinity Mother Frances Hospital, Tyler, Texas
• 1994 - Present: Acting Staff - East Texas Medical Center Hospital, Tyler, Texas
• 1994 - Present: Consulting - East Texas Medical Center Hospital, Quitman, Texas
• 1994 - Present: Consulting - East Texas Medical Center Hospital, Crockett, Texas
• 1994 - Present: Consulting - East Texas Medical Center Hospital, Mount Vernon, Texas
• 1994 - Present: Consulting - East Texas Medical Center Hospital, Pittsburg, Texas
• 1994 - Present: Consulting - East Texas Medical Center Hospital, Athens, Texas
• 1997 - Present: Consulting - East Texas Medical Center Hospital, Jacksonville, Texas
• 1997 - Present: Consulting - Laird Memorial Hospital, Kilgore, Texas

Professional Societies, Activities and Other Memberships

• 2003 - Present: Medical Executive Committee- Trinity Mother Frances Hospital, Tyler, Texas
• 1996 - Present: Fellow, American College of Cardiology
• 1997 - Present: Director - Heart Care Partnership - East Texas Medical Center
• 1997 - 2001: Director of Research - East Texas Medical Center Cardiovascular Institute
• 1997 - 1998: President - American Heart Association - Smith County
• 1996 - Present: Lipid Clinic Director - Cardiovascular Associates of East Texas
• 1996 - Present: Director of Clinical Services - Cardiovascular Associates of East Texas
• 1999 - 2000 Credentials Committee - East Texas Medical Center
• 1994 - Present: American Heart Association - Smith County - Board of Directors
• 1994 - Present: American College of Cardiology
• 1994 - Present: American Medical Association
• 1994 - Present: Texas Medical Association
• Past: Smith County Medical Society
• Past: California Medical Society
• Past: American College of Physicians
• Past: Christian Medical Society
• Past: American Society of Echocardiography
• 1993 UCLA Medical Center - Managed Care Committee
• 1989 - 1994 UCLA Coronary Care and Cardiac Observation Unit Committees
• Arteriosclerosis and Thrombosis - Manuscript Reviewer
• American Journal of Cardiology - Manuscript Reviewer

Publications

• Carr JG, Stevenson LW, Walden J, Heber D: Prevalence and hemodynamic correlations of malnutrition in severe congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy.
  American J. Cardiology 1989; 63; 709-713
• Carr JG, Johnson JA, Kobashigawa JA, Sack JB, Yeatman LA: Does the vasodilator response to nitroglycerin over time affect quantitative assessment of coronary artery lesion dimensions using intravascular ultrasound? J. of the American College of Cardiology 1994; SI:243A
• Carr JG, Miller L, Anderson TF, Murali S, Ventura H, Gordon J, Wilensky R, Yeung AC: Does steroid-free immunosuppression influence the degree of intimal thickening after heart transplantation? A multicenter Study, Circulation, 1994;90:638A
• Kobashigawa JA, Gleeson MP, Stevenson LW, Carr JG, Moriguchi JD, Kawata N, Hamilton MA, Hage A, Drinkwater D, Laks H: Prevention of severe cardiac allograft rejection with Pravastatin: A randomized trial. Journal of the American College of Cardiology 1994;SI:483A
• Johnson JA, Kobashigawa JA, Yeatman L, Carr JG, Trosian KD, Sabad A, Wener LS, Drinkwater D, Laks H: Does pre-existing donor heart atherosclerosis lead to more transplant coronary artery disease? A prospective study using morphometric analysis of intracoronary ultrasound. Journal of American College of cardiology, 1996;2:144A
• Johnson JA, Kobashigawa JA, Yeatman L, Carr JG, Trosian KD, Sabad A, Wener LS, Drinkwater D, Laks H. The distribution and characteristics of transplant coronary disease in a prospective morphometric analysis of intracoronary ultrasound. Journal of American College of Cardiology, 1996:27A

Research

• Principal Investigator - ACUITY Trial- A randomized comparison of Angiomax (bivalirudin) versus Lovenox/Clexane (enoxaparin) in patients undergoing early invasive management for acute coronary syndrome without ST-segment elevation.
• Principal Investigator - REPLACE II - A Randomized Evaluation in PCI Linking Angiomax to Reduced Clinical Events, Part 2: REPLACE-2 (TMC-BIV-01-03)
• Principal Investigator - REPLACE - TMC-BIV-00-01, Randomized Evaluation in Percutaneous Coronary Intervention Linking Angiomax to Reduced Clinical Events.
• Principal Investigator - Otsuka Protocol 21-98-214-01 CASTLE " A Randomized, Double-Blind, Placebo-Controlled, Multicenter, Parallel-Arm, Study to Asses The Long-Term Effects of Pletal® (Cilostazol) Versus Placebo Administered Orally to Patients with Intermittent Claudication Secondary to Peripheral Arterial Disease."
• Principal Investigator - GUSTO IV ACS - A Phase III, Randomized, Double-Blind, Placebo-Controlled Trial Evaluating the Efficacy and Safety of ReoProT, Given as a Bolus Followed by a 24- or 48-Hour Infusion, for the Treatment of Acute coronary Syndrome Without ST-Segment Elevation.
• Principal Investigator - Left Main IVUS Registry - Scripps Clinic - A multicenter prospective registry designed to determine the value of diagnostic IVUS in the setting of an inconclusive coronary angiogram.
• Principal Investigator - PRAISE 2 - (Prospective Randomized Amlodipine Survival Evaluation -2) Phase III Protocol NO. 053-185: A randomized, double-blind, dose-titration, parallel group, placebo-controlled study to evaluate the effect of Amlodipine on survival in patients with congestive heart failure.
• Principal Investigator - AMISTAD II Trial (Phase III): A randomized, double-blind, placebo-controlled, multicenter trial to evaluate the efficacy and safety of Adenosine (Pallacor, Adenosine Injection) as an adjunct to reperfusion therapy (Thrombolysis or Mechanical Reperfusion) in the treatment of acute anterolateral myocardial infarction.
• Principal Investigator - ATLAS Trial (Aspirin TicLid vs Anticoagulation for Stents) - George Washington University, Cardiovascular Research Institute.
• Principal Investigator - Niaspan Trial #MA-97-0101 Phase IV: an open-label, community-based clinical practice study of Niaspan in patients with hyperlipidemia.
• Principal Investigator - Intravascular Ultrasound Core Imaging Laboratory (Syntax MUCS1864 TCAD) Randomized, double-blind comparative study of Mycophenolate Mofetil or Azathioprine each in combination with Cyclosporine and corticosteroids for the prevention of rejection in cardiac allograft recipients.
• Co-Investigator - A Multicenter, Randomized, Double-blind, Placebo Controlled Study to Evaluate the Efficacy and Safety of Ad5FGF-4 in Patients with Stable Angina
• Co-Investigator - AMIHOT - TherOx Aqueous Oxygen System - Acute Myocardial Infarction with Hyperoxemic Therapy "AMIHOT" Phase II clinical trial. A Randomized, Controlled, Multicenter Trial of Aqueous Oxygen Infusion for 90 Minutes Post-Primary PTCA/Stent Intervention in Acute Myocardial Infarction Patients.
• Co-Investigator - SYNERGY - A Prospective, Randomized, Open-Label, Multicenter Study in Patients Presenting with Acute Coronary Syndromes (ACS). Aventix Pharmaceuticals Protocol Number ENO.GMA.301. IND# 31532
• Co-Investigator-INSPIRE :A Randomized, Prospective Multicenter Trial Evaluating The Role Of Adenosine Tc99m Sestamibi SinglepPhoton Emission Computed Tomography For Assessing Risk And Therapeutic Outcomes In Survivors Of Acute Myocardial Infarction.
• Co-Investigator - A Double-Blind Comparison Of The Incidence Of Hypotension With Two Formulations Of Intravenous Amiodarone: Cordarone ® I.V. vs Amiodarone Aqueous I.V. Injection - Protocol No. 058K1-312-US
• Co-Investigator - OCTAVE - CV137-120 Omapatrilat Cardiovascular Treatment Assessment Versus Enalapril (OCTAVE) A Phase III, Randomized, Double Blind, Active Controlled Comparision of Omapatrilat and Enalapril in Subjects with newly Diagnosed or Established Hypertension
• Co-Investigator - CRISP - A single Arm, Open label Study of Cervastatin (Baycol®) in Community based Patients with Hypercholesterolemia at risk for Cardiovascular Disease and patients with Cardiovascular Disease. To Monitor inflammatory markers
• Co-Investigator - ER TIMI 19 - A Phase IV Open-Label Trial of Prehospital Administration of Retavase â for ST elevation MI - the Early Retavase â (ER)-TIMI 19 Trial.
• Co-Investigator - STEP AMI - An Open Study, with Blinded Endpoint Assessment, to Assess the Safety, Tolerability and the Effect on Coronary Artery Patency of Intravenous AR-C69931MX as both Monotherapy and Adjunct to Activase in Patients with ST-elevation Myocardial Infarction.
• Co-Investigator - MICCAT ( MICardis Community Access Trial) An Phase IV - Open label evaluation of the effectivness of Micardis â ( telmisartan) on blood pressure control and quality of life in patients with essential hypertension.
• Co-Investigator - VALIANT Trial Phase III (VALsartan In Acute myocardial iNfarcTion): A multinational, multicenter, double-blind, randomized, active controlled, parallel group study comparing the efficacy and safety of long-term treatment with Valsartan, Captopril and their combination in high risk patients after myocardial infarction.
• Co-Investigator - VALIANT REGISTRY SUBSTUDY : VALIANT Trial Phase III (VALsartan In Acute myocardial iNfarcTion): A multinational, multicenter, double-blind, randomized, active controlled, parallel group study comparing the efficacy and safety of long-term treatment with Valsartan, Captopril and their combination in high risk patients after myocardial infarction.
• Co-Investigator - EPHESUS - IE-99-02-035, Clinical protocol for a double blind, randomized, placebo-controlled trial to evaluating the safety and efficacy of eplerenone in patients with heart failure following acute myocardial infarction.
• Co-Investigator - GUSTO IV AMI (Protocol CO116T31): A phase III, randomized, open-label trial evaluating the efficacy and safety of ReoPro TM (ABCIXIMAB) in combination with reduced dose Retavase TM / Rapilysin TM (Recombinant Plasminogen Activator, Reteplase, r-PA) for the treatment of acute myocardial infarction.
• Co-Investigator - Paragon B Trial: A randomized, double-blind, placebo-controlled study of Lamifiban (RO44-9883) in patients with unstable angina/non Q wave myocardial infarction.
• Co-Investigator - PACT trial (Plasminogen-Activator Angioplasty Compatibility Trial) A randomized, double-blind placebo controlled study assessing clinical efficacy of bolus infusion TPA to placebo in acute MI patients with rescue angioplasty.
• Co-Investigator - Coumadin, Aspirin and Reinfarction Study; "CARS" Dup 647-003-459. A randomized, double-blind study to compare the efficacy and safety of fixed low doses of Coumadin plus aspirin to aspirin alone in the prevention of reinfarction, cardiovascular death, and stroke in post-myocardial infarction patients.
• Co-Investigator - CARS (Coumadin, Aspirin and Reinfarction Study) EKG Substudy Dup647-003-459. A randomized, double-blind study to compare the efficacy and safety of fixed low doses of Coumadin plus aspirin to aspirin alone in the prevention of reinfarction, cardiovascular death, and stroke in post-myocardial infarction patients.
• Co-Investigator - CardioGenesis Transmyocardial Revascularization (TMR) System: To evaluate the safety and efficacy of the CardioGenesis TMR System when used for TMR performed as an adjunct to CABG in patients with angina resulting from coronary artery disease which is only partially treatable by CABG.
• Co-Investigator - TMR012-A. A Single-Blind Randomized Study of the Safety and Effectiveness of Percutaneous Transluminal Myocardial Revascularization (PTMR) Performed with the Eclipse Holmium Laser as an Adjunct to Percutaneous Coronary Intervention
• Co-Investigator - IMDUR (Isosorbide Mononitrate) Patient Acceptability Program. A study comparing the efficacy, safety and ease of use of three FDA-approved formulations; IMDUR, ISDN, and ISMO. The study design assesses if patients with stable angina pectoris benefit in terms of fewer anginal attacks, increased exercise tolerance, simplicity and convenience of use.
• Clinical Investigator - Multicenter trial prospectively evaluating the natural history of transplant coronary artery disease (TCAD) assessed by intravascular ultrasound (IVUS).
• Randomized trial on the effects of lipid lowering with Pravastatin on cardiac transplant rejection and TCAD assessed by IVUS.
• Co-Investigator - (NRMI) National Registry for Myocardial Infarction.
• Co-Investigator - Extra Point. Protocol # S1710202. Cardiovascular Safety Study of Nicotine Transdermal System

Honors/Awards

Internal Medicine Honors

• Phi Beta Kappa
• Magna Cum Laude
• Blue Key National Honor Fraternity
• 1991 - 1992: UCLA Medical Center's Outstanding Teacher (Fellow)
• 1991 - 1992: UCLA (Nurses') Physician of the Year

Professional Qualifications/Certifications

• Coronary and peripheral vascular diagnostic angiography and percutaneous interventions
• Vascular Brachytherapy - Beta - Gamma
• Aortic Endograft placement - ANCURE
• Stent Placement - Coronary and Peripheral
• Distal Embolization protection -
  • Filter Wire (BSCI)
  • Percusurge (Medtronic)
• Atherectomy- Coronary and peripheral
  • Laser Atherectomy- Excimer
  • Rotablator -Percutaneous Transluminal Coronary Rotational Atherectomy
  • Coronary and Peripheral
  • Transluminal Extraction Catheter
  • Directional Coronary Atherectomy
  • Intravascular Ultrasound (IVUS) - Coronary and Peripheral
  • Translesional Pressure wire measurement
  • Angiojet Thrombectomy
• Transesophageal Echocardiography
• Stress ECHO